Microbiome（2017/10-2022/9）

A wide variety of microorganisms live in various parts of the human body in a symbiotic manner. These symbiotic microorganisms play very important roles for human to maintain physiological functions. Our research group has focused on the intestinal and skin microflora to identify microorganisms that aggravate pathological conditions and those that have therapeutic effects. We have also analyzed the mechanism of action of the bacterial cocktail we have obtained　through this project.

Main research participants (affiliation and position at the time)

Kenya HONDA (Professor, Department of Microbiology and Immunology, Keio University School of Medicine)

Research Field: Microbiome

Masayuki AMAGAI (Professor, Department of Dermatology, Keio University School of Medicine)

Research Field: Skin flora

Takanori KANAI (Professor, Department of Gastroenterology and Hepatology, Keio University School of Medicine)

Research Field: Inflammatory diseases of the digestive tract

Publication

Identification of trypsin-degrading commensals in the large intestine.
Li Y, Watanabe E, Kawashima Y, Damian R Plichta , Zhujun Wang , Ujike M, Qi Yan Ang , Runrun Wu , Furuichi M, Takeshita K, Yoshida K, Nishiyama K, Sean M Kearney , Suda W, Hattori M, Sasajima S, Matsunaga T, Xiaoxi Zhang , Watanabe K, Fujishiro J, Jason M Norman , Bernat Olle , Matsuyama S, Ho Namkoong , Uwamino Y, Ishii M, Fukunaga K, Hasegawa N, Ohara O, Ramnik J Xavier , Atarashi K, Honda K.
Nature. 609:582-589 (2022)

Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis.
Ichikawa M, Nakamoto N, Kredo-Russo S, Weinstock E, Weiner IN, Khabra E, Ben-Ishai N, Inbar D, Kowalsman N, Mordoch R, Nicenboim J, Golembo M, Zak N, Jablonska J, Sberro-Livnat H, Navok S, Buchshtab N, Suzuki T, Miyamoto K, Teratani T, Fujimori S, Aoto Y, Konda M, Hayashi N, Chu PS, Taniki N, Morikawa R, Kasuga R, Tabuchi T, Sugimoto S, Mikami Y, Shiota A, Bassan M, Kanai T.
Nat Commun. 14:3261 (2023)