Stem Cell Biology & Cell Based Medicine(2017/10~2022/9)

Stem cells possess both self-renewal and differentiation potential. Organoids, in which stem cells self-organize to reproduce tissue structure and function, are useful tools for elucidating disease mechanisms and developing new treatments. We have been engaged in the development of organoid culture technology and the application research of various evaluation models.


Main research participants (affiliation and position at the time)

Hideyuki OKANO (Professor, Department of Physiology, Keio University School of Medicine)
Research Field: Brain organoid

Toshiro SATO (Professor, Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine)
Research Field: Gastrointestinal organoid

Tatsuyuki CHIYODA (Assistant Professor, Department of Obstetrics and Gynecology, Keio University School of Medicine)
Research Field: Gynecological cancer

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Publication

An organoid-based organ-repurposing approach to treat short bowel syndrome.
Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Takahashi S, Nanki K, Hakamata Y, Kanai T, Sato T.
Nature. 592:99-104 (2021)